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Journal of Intelligent Material Systems and Structures
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A Self-Regulated Insulin Delivery System Using Boronic Acid Gel

Daijiro Shiino

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, NOF Corporation Tsukuba Research Laboratory Tokodai 5-10 Tsukuba-shi, Ibaraki 300-26 Japan

Kazunori Kataoka

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, Department of Materials Science and Research Institute for Biosciences Science University of Tokyo Yamazaki 2641 Noda-shi, Chiba 278 Japan

Yoshiyuki Koyama

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, Research Institute for Biosciences Science University of Tokyo Yamazaki 2669-1 Noda-shi, Chiba 278 Japan

Masayuki Yokoyama

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, Institute of Biomedical Engineering Tokyo Women's Medical College Kawada-cho 8-1 Shinjuku-ku, Tokyo 162 Japan

Teruo Okano

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, Institute of Biomedical Engineering Tokyo Women's Medical College Kawada-cho 8-1 Shinjuku-ku, Tokyo 162 Japan

Yasuhisa Sakurai

International Center for Biomaterials Science (ICBS) Yamazaki 2669-1 Noda-shi, Chiba 278 Japan, Institute of Biomedical Engineering Tokyo Women's Medical College Kawada-cho 8-1 Shinjuku-ku, Tokyo 162 Japan

A novel polymer system sensitive to glucose concentration has been studied as a can didate material for chemically regulated insulin release system. Phenylboronic acid is able to form reversible binding to cis-diol substances. A glucose responsive insulin release system has been studied with utilization of phenylboronic acid polymers for the key material in the exchange reaction between gluconic acid modified insulin (G-Ins) and glucose. The released concentration of G-Ins from the polymer was pulsatile in response to the repeated stepwise concentration changes of glu cose. The linearity between glucose concentration and peak height of released G-Ins and the release response demonstrated no lag time to changes in glucose concentration were other important finites. The phenylboronic acid polymer shows considerable promise for use in a self-regulating insulin delivery system.

Journal of Intelligent Material Systems and Structures, Vol. 5, No. 3, 311-314 (1994)
DOI: 10.1177/1045389X9400500303
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